Juergen W Czarske (Fellow EOS, OPTICA, SPIE, IET, IOP, Senior Member IEEE) is director, full chair professor and senator of the Excellence University TU Dresden, Germany. He is director of Competence Center Biomedical Computational Laser Systems (BIOLAS) and advisor of SPIE-OPTICA-Student Chapter Dresden. Juergen is an international prize-winning inventor of laser-based technologies. His awards include the 2008 Berthold Leibinger Innovation Prize of Trumpf Laser Systems, 2019 OPTICA Joseph-Fraunhofer-Award/Robert-M.-Burley-Prize, 2020 Laser Instrumentation Award of IEEE Photonics Society, 2020 and 2021 SPIE Community Champion for volunteer activities, and 2022 SPIE Chandra S Vikram Award. Juergen has conducted more than 1000 talks and papers, including more than 250 papers in peer-reviewed journals, over 150 invited talks and over 30 patents. He is Vice President of International Commission for Optics, ICO, and was the general chair of the world congress ICO-25-OWLS-16-Dresden-Germany-2022 with 3 Nobel laureates and participants from 55 countries of 5A (Africa, America, Asia, Australia, and Amazing Europe).

    Light has the potential to recognize the origins of diseases, enabling to prevent them, or to cure them early and gently. The early diagnosis is the key to improve the survival rate and cure rate of patients. Endoscopy plays an important role in the early stages of diagnosis by a guiding biopsy. However, conventionally it takes several hours to a few days for the surgeon to know the results of the diagnosis. Optical histopathology offers real-time intraoperative diagnosis without tissue removal. We demonstrate lensless imaging with multicore fibers using deep neural networks and wavefront shaping with femtosecond laser-based 3D printed holograms. It is promising for minimally invasive intraoperative diagnostics of cancer in neurosurgery. Furthermore, we present novel concepts of diffuser endoscopy and 3D quantitative phase imaging (QPI) of rotated cancer cells by fiber-based traps. The Cambrian explosion of advanced smart laser endomicroscopy towards paradigm-shifts for biomedicine is highlighted.