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9月20日学术报告

来源: 发布时间:2010-09-15【字体:

报告题目:Photophysics and Photochemistry Properties of Flavin cofactor and DNA Photolayse Investigated by Ultrafast Spectroscopy

报告人:李桂峰博士

时间:9月20日(星期一)下午1:30 地点: 缘园 溢智厅

报告内容简介:

Photophysics and Photochemistry Properties of Flavin cofactor and DNA Photolayse Investigated by Ultrafast Spectroscopy

Guifeng Li

Department of Chemistry, Emory University, Atlanta, GA

Abstract

Flavin cofactors are well-known electron-shuffle agents in biological systems due to their high reduction potentials and flexibility in mediating either one- or two-electron transfer processes. Flavoproteins are also known to perform light-driven catalysis. For example, phototropins and BLUF proteins regulate bending of plants and motion of microorganism toward light. In these proteins, the flavin cofactor is in its oxidized state.The reduced flavin cofactor is present in DNA photolyase and cryptochrome protein families. However, photophysics and photochemistry properties of flavin cofactor and its reduced form are not understood well. DNA photolayse also remains unknown question such as the role of adenine in DNA repair process.

To answer above question, we use ultrafast spectroscopy (VIS and infrared range) to investigate two important flavin cofactors, flavin mononucleotide (FMN) and flavinadenine dinucleotide (FAD). First experimental evidence of intra-electron transfer in FAD is provided by Time-resolved Infrared Spectroscopy (TRIR). Further, two reduced flavin cofactors such as flavin-mononucleotide (FMNH2) and flavin-adenine dinucleotide (FADH2) have been studied. We firstly observed adenine group play an important role in DNA photolayse, which support two-step electron transfer process mechanism.

报告人简介:

Guifeng Li received his B.Sc. degree and M.Sc. from department of physics, Henan University on 1998 and 2001, respectively. On July, 2001, he went to Hokkaido University in Japan for his Ph.D degree and received it from materials science (nonlinear optics) on 2005. He received 2004 Chinese Government Award for Outstanding Selffinanced Student Abroad from China Scholarship Council. From 2005, he started to carryout his postdoctoral researches (nonlinear optics and ultrafast spectroscopy) in The University of Akron (polymer science), ExxonMobil, and Bowling Green State University.Currently, he is postdoc research associate at Department of Chemistry, Emory University.

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2010/9/15


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